RNA Modification and Processing

Welcome to Transregio 319 RMaP

What is RMaP?

Transregio 319 RMaP is a joint venture combining:

Molecular Biology, Biochemistry, Cellular Biology, Chemical Biology, Biophysical Chemistry, Structural Biology, Developmental Biology, Genetics, Bioinformatics.

Principal Investigators of RMaP

Fabian Barthels

JGU

Falk Butter

JGU
A03, C03

Tamer Butto

JGU

Prof. Dr. Alexander Dalpke

TU-Dresden
A03

Prof. Dr. Christoph Dieterich

Uni-HD
B01, C02

Prof. Dr. Michaela Frye

UDKFZ
A01

Prof. Dr. Mark Helm

JGU
A05, C01, C03

Dr. Martin Hengesbach

JGU
B06

Prof. Dr. Andreas Hildebrandt

JGU
C01, C02

Prof. Dr. Andres Jäschke

Uni-HD
A02, C03

Prof. Dr. René Ketting

JGU
B04

Dr. Julian König

JGU
B01

Prof. Dr. Frank Lyko

DKFZ
A01

Prof. Dr. F. Nina Papasvasiliou

DKFZ
A04

Dr. Jirka Peschek

Uni-HD
A06

Prof. Dr. Jean-Yves Roignant

JGU
B01

Dr. Alessia Ruggieri

Uni-HD
A05, IRTG

Prof. Dr. Tanja Schirmeister

JGU
A01

Bertil Schmidt, Prof. Dr.

JGU
C01

Prof. Dr. Irmgard Sinning

Uni-HD
B03

Prof. Dr. Dr. Georg Stöcklin

Uni-HD
A04

Dr. Francesca Tuorto

Uni-HD
A06

Dr. Marie-Luise Winz

JGU
B05

Structure of RMaP

A „Modificationslook for Processing“

B „Processing looks for Modifications“

C „New RNA Technology for RMaP“

TRR Speaker Office

Prof. Dr. Mark Helm

Speaker

Dr. Marion Stemke

Executive officer and Coordinator

Claudia Alihodzic

Administrator TRR319

Doris Ebeling

Administration & Equal Opportunity officer

Doris Gebhardt

Administration & Equal opportunity officer

Members of the Scientific Board

Recent publications from the TRR 319

Podvalnaya N, Bronkhorst AW, Lichtenberger R, Hellmann S, Nischwitz E, Falk T, Karaulanov E, Butter F, Falk S, Ketting RF. piRNA processing by a trimeric Schlafen-domain nuclease. Nature. 2023 Oct;622(7982):402-409. doi: 10.1038/s41586-023-06588-2. Epub 2023 Sep 27. PMID: 37758951; PMCID: PMC10567574.

Motorin Y, Helm M. General Principles and Limitations for Detection of RNA Modifications by Sequencing. Acc Chem Res. 2023 Dec 8. doi: 10.1021/acs.accounts.3c00529. Epub ahead of print. PMID: 38065564.

Helm M, Bohnsack MT, Carell T, Dalpke A, Entian KD, Ehrenhofer-Murray A, Ficner R, Hammann C, Höbartner C, Jäschke A, Jeltsch A, Kaiser S, Klassen R, Leidel SA, Marx A, Mörl M, Meier JC, Meister G, Rentmeister A, Rodnina M, Roignant JY, Schaffrath R, Stadler P, Stafforst T. Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications. ACS Chem Biol. 2023 Nov 14. doi: 10.1021/acschembio.3c00586. Epub ahead of print. PMID: 37962075.

Sung HM, Schott J, Boss P, Lehmann JA, Hardt MR, Lindner D, Messens J, Bogeski I, Ohler U, Stoecklin G. Stress-induced nuclear speckle reorganization is linked to activation of immediate early gene splicing. J Cell Biol. 2023 Dec 4;222(12):e202111151. doi: 10.1083/jcb.202111151. Epub 2023 Nov 13. PMID: 37956386; PMCID: PMC10641589.

Sun Y, Piechotta M, Naarmann-de Vries I, Dieterich C, Ehrenhofer-Murray AE. Detection of queuosine and queuosine precursors in tRNAs by direct RNA sequencing. Nucleic Acids Res. 2023 Nov 10;51(20):11197-11212. doi: 10.1093/nar/gkad826. PMID: 37811872; PMCID: PMC10639084.

Möhler M, Jäschke A. Future Perspectives for the Identification and Sequencing of Nicotinamide Adenine Dinucleotide-Capped RNAs. Acc Chem Res. 2023 Nov 7;56(21):3000-3009. doi: 10.1021/acs.accounts.3c00446. Epub 2023 Oct 18. PMID: 37852615; PMCID: PMC10634297.

Sun Y, Piechotta M, Naarmann-de Vries I, Dieterich C, Ehrenhofer-Murray AE. Detection of queuosine and queuosine precursors in tRNAs by direct RNA sequencing. Nucleic Acids Res. 2023 Oct 9:gkad826. doi: 10.1093/nar/gkad826. Epub ahead of print. PMID: 37811872.

Podvalnaya N, Bronkhorst AW, Lichtenberger R, Hellmann S, Nischwitz E, Falk T, Karaulanov E, Butter F, Falk S, Ketting RF. piRNA processing by a trimeric Schlafen-domain nuclease. Nature. 2023 Oct;622(7982):402-409. doi: 10.1038/s41586-023-06588-2. Epub 2023 Sep 27. PMID: 37758951; PMCID: PMC10567574.

A continuously updated publication list can be found here.

Upcoming Events

RMaP Retreat January 2024 @ Heidelberg

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Career crafting for females

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Leading Successfully

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